Which liver enzyme is NOT included in a CMP?

• A. Alanine aminotransferase (ALT)
• B. Aspartate aminotransferase (AST)
• C. Alkaline phosphatase (ALP)
• D. Gamma-glutamyl transpeptidase (GGT)

Answer: (D)

A Comprehensive Metabolic Panel (CMP) is a blood test that includes a variety of markers, primarily aimed at assessing the function of various organ systems, including the liver. The CMP typically measures liver enzymes such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), and Alkaline phosphatase (ALP), which are important indicators of liver health and function.

Gamma-glutamyl transpeptidase (GGT), while also a liver enzyme, is not included in the standard CMP. This enzyme is often measured separately in cases where more detailed insight into liver function or biliary obstruction is needed. Its specific role in assessing conditions like alcoholism or cholestasis makes it useful but not universally included in the CMP, which focuses on a broader metabolic assessment.

Understanding the distinctions between these liver enzymes and their inclusion in various panels is essential for interpreting laboratory results and determining the necessary follow-up tests for liver health assessments.